EB Biobank

The EB Biobank consists of systemically collected and processed biological samples and related clinical data with a focus on EB patients.

The sample diversity and the detailed patient data including scRNAseq data allows us unprecedented insight into pathogenic events especially for rare diseases.

The EB Biobank is the ideal starting point for translational research:

A diverse range of samples with comprehensive patient data:

Patient data

Core Data
• EB type, gene mutation, age of patient at time of sampling, diagnostic indication

Sample-associated data
• Type of wound, age of wound, itch and pain score, topical treatments, type of dressing

Digital pictures
• Wounds and SCC

iScoreEB Data
• incl. subscores, longitudinal data

The EB Biobank features a diverse collection of samples:

Biological Samples

Types of samples

• Tissue (OCT / SNAP frozen / FFPE blocks / Trizol, RNA)
• Wound bandage cells
• Blood (serum, plasma)
• Microbiome (swabs, stool)
• Urine

Types of collections

• Cross-sectional samples
• Longitudinal samples

Insight into EB pathomechanisms at cellular level:

EB Cell Atlas

• The currently existing EB Cell Atlas consists of severe and generalized intermediated RDEB and JEB samples

• This allows us to map key molecular and cellular mechanisms that might drive disease severity in RDEB

• The diversity of samples enables mapping different features of the disease manifestation

Diverse cell types from multiple tissues and donors:

EB Hub

• Cells are isolated from skin, tumortissue, oral tissue und wound bandage

• Reflects a range of disease stages, severities, and patient heterogeneity

• Primary and immortalized cell lines

• Patient matching cell lines

EBS: Epidermolysis bullosa simplex, JEB: Junctional Epidermolysis bullosa, DDEB: Dominant dystrophic Epidermolysis bullosa, RDEB: Recessive dystrophic Epidermolysis bullosa, HC: healthy control;